Human Sera
Cayman Chemical Butenoyl PAF 50mg
An internal standard for the quantification of phosmet by GC- or LC-MS
Cayman Chemical TIplaxtInIn 50mg
A derivative of thalidomide inhibits the proliferation of EA.hy926 endothelial cells (IC50 200 UM) an intermediate in the synthesis of a PROTAC c-MET degrader with antiproliferative activity in c-MET-sensitive cancer cells an intermediate in the synthesis of a thalidomide derivative that reduces clinical scores in a mouse model of EAE
Cayman Chemical 2MethoxymethcathInonhydro 50mg
A fluorogenic substrate for chymotrypsin and chymotrypsin-like proteases AMC is released upon enzymatic cleavage by proteases and its fluorescence can be used to quantify protease activity ex/em 340-360/440-460 nm respectively
Cayman Chemical 1Pentadecnoylracglycerol 100mg
An esterified form of trans-vaccenic acid has been used as a standard for the identification and quantification of fatty acids in Uruguayan Colonia cheese by GC-MS
Cayman Chemical 1Pentadecnoylracglycerol 50mg
A PRDM9 inhibitor (IC50 80 nM) inhibits PRDM9-dependent trimethylation of ectopic histone H3K4 (IC50 0 8 UM) and endogenous H3K4 in HEK293 cells in a concentration-dependent manner induces meiotic defects in mouse spermatocytes
Cayman Chemical TerlIpresInacetate 100mg
An IMP1 inhibitor (IC50 5 M for IMP1 binding to c-Myc mRNA) downregulates c-Myc andBTrCP1 mRNA and reduces IMP1 protein levels in SK-MEL-2 and IGROV-1 cells inhibits proliferation of IMP1-positive ES-2 IGROV-1 and SK-MEL-2 cells (IC50s 2 3 3 6 and 4 5 M respectively) inhibits anchorage-independent growth of SK-MEL-2 cells at 10 M
Cayman Chemical LumIracoxIb 50mg
A mixture of alkaloids with diverse biological activities blocks norepinephrine-induced reflex vasodilation and vasoconstriction in dogs when injected into the kidney at a dose of 0 15 mg blocks norepinephrine-induced cAMP production in rat brain cortical homogenates ex vivo in a dose-dependent manner acts as an erectogenic agent in rats
Cayman Chemical BenznIdazole 50mg
A metabolite and degradation product of the pesticide DDT accumulates in various fish and sediment surrounding a DDT manufacturing plant inhibits estrogen binding to rtERs (IC50 3 2 M) induces concentration-dependent secretion of estradiol by granulosa and theca cell co-cultures isolated from porcine ovarian follicles induces concentration-dependent secretion of estradiol by granulosa and theca cell co-cultures isolated from porcine ovarian follicles increases degeneration of ovarian follicles and reduces testicular size in Japanese medaka (O latipes)
Cayman Chemical Pnaxatrol 50mg
A mineralocorticoid agonist promotes sodium retention in rats in a dose-dependent manner with 37 of sodium excreted compared with control when used at a dose of 5 Ug/animal
Cayman Chemical Valerolactone 50mg
An agonist of NPY receptors reduces forskolin-induced cAMP accumulation in L-M(TK-) cells recombinantly expressing human and rat Y4 receptors (EC50s 87 1 and 36 3 pM respectively) binds to human Y1 and Y5 receptors (Kis 19 and 3 9 nM respectively) induces contractile responses in isolated rat colon (EC50s 1 6 and 0 7 nM for ascending and descending colon segments respectively) increases food intake in rats (0 7-7 nmol i c v )
Cayman Chemical NalmefenhydrochlorIde 100mg
An a-hydroxy acid levels are increased in 2-hydroxyglutaric aciduria can be metabolized from isocitrate by mutated forms of IDH1 and IDH2 competitively inhibits a-ketoglutarate-dependent dioxygenases including histone lysine demethylases and DNA hydroxylases
Cayman Chemical PInoresInol DIglucosIde 50mg
An analytical reference standard categorized as a nootropic prevents scopolamine-induced memory deficits in rats intended for research and forensic applications
Cayman Chemical PentagastrIn 50mg
A cyanoacetamide fungicide inhibits the mycelial growth of 12 isolates of P infestans (EC50s - 0 27-0 57 g/mL) inhibits the growth of several strains of S cerevisiae (IC50s 8-25 mg/l) reduces blighted leaves of P infestans-infected potato plants and P cubensis-infected cucumber plants by 79 and 60 respectively at 1 mg/ml toxic to rats (LD50 3 8 mmol/kg)
Cayman Chemical Coydals ynusuo Coydaln 100mg
An inhibitor of Src and p38 MAPK kinases (Kds 2 7 2 2 and 5 5 nM for c-Src p38a and p38B respectively) also inhibits Fyn Yes Lyn Abl Arg Ack Csk EphB2 EphB4 and Zak at 500 nM inhibits cell growth in a panel of TNBC cell lines (IC50s 6 1-260 nM) and in a patient-derived TNBC cell line (IC50 320 nM) induces cell cycle arrest at the G1/S phase MDA-MB-231 and SUM149 cells at 1 M inhibits cell motility and invasion in MDA-MB-231 and SUM149 cells at 50 nM reduces tumor growth in SUM149 and MDA-MB-231 mouse xenograft models at 10 mg/kg